In 1915, at the age of 20, she married the artist Maynard Dixon. They soon moved to San Francisco where Dorothea established her own studio. In 1925 their first child Daniel Dixon was born, in 1929 Lange gave birth to her second and last child named John.
However, Lange's family happiness was not long and the couple went through many hardships. The hardest period was Great Depression of 1929-1930s. Shortly before, a series of mass robberies took place throughout the city, and with the onset of the Great Depression, to save money on everything, the family began living right in Dorothea's studio.
It was then that she began to shoot reportages of the demonstrations, the effects of the crisis and the migrant workers in the Salinas Valley. Those photographs brought Lange instant fame, but they were also the reason of her divorce. She was constantly traveling and could not spend much time with her family. One day she was suddenly called to San Francisco to document another demonstration. This hasty departure in the middle of a planned and infrequent family vacation was the last straw and in 1935 the couple divorced.
That same year Dorothea married economist Paul Taylor. He told her about the origins of the social and economic problems prevailing in the country, and thereafter often traveled with her.